Smartox-Biotech
Smartox Biotechnology
離子通道研究用多肽**的專(zhuān)業(yè)化生產(chǎn)商
Smartox Biotechnology是全球唯壹一家專(zhuān)門(mén)生產(chǎn)動(dòng)物毒液多肽**，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽**在生物制藥領(lǐng)域具有重要的使用價(jià)值。
Smartox Biotechnology于2009年由來(lái)自Grenoble神經(jīng)科學(xué)研究所(Grenoble Institute of Neuroscience)的Michel de waard博士創(chuàng)立,Smartox Biotechnology專(zhuān)門(mén)研究動(dòng)物毒液，制作合成多種毒液中的多肽成分（常稱(chēng)為**）。De Waard博士研究離子通道與**多肽的關(guān)系，尤其是鑒定、開(kāi)發(fā)**多肽作為**性分子或細(xì)胞穿透肽(cell penetrating peptides, CPP)。其研究團(tuán)隊(duì)在毒液分離，藥理性活性肽鑒定、富半胱氨酸肽定性、制作和優(yōu)化等方面具有獨(dú)特、豐富的經(jīng)驗(yàn)。2010年，Smartox Biotechnolgy被法國(guó)研究部(Ministry of Research)授予“新興企業(yè)OSEO獎(jiǎng)(OSEO prize for emerging businesses)”。
總之，Smartox Biotechnology提供一系列高質(zhì)量、具開(kāi)創(chuàng)價(jià)值的多肽**。這些化合物在離子通道 研究中具有高的親和性和選擇性，是相應(yīng)領(lǐng)域科學(xué)研究理想的生物**提供商和貼心的合作伙伴。
Smartox Biotechnology的**產(chǎn)品包括：
鈉離子通道(Sodium channel)
|
Toxin name |
Catalog # |
Target |
|
Phrixotoxin-3 |
13PHX003 |
Selective blocker of Nav1.2 |
|
μ-conotoxin GIIIB |
CON020 |
Selective blocker of Nav1.4 |
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μ-conotoxin CnIIIC |
CON021 |
Selective blocker of Nav1.4 |
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μ-conotoxin PIIIA |
08CON006 |
Selective blocker of Nav1.4 |
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Jingzhaotoxin-III |
12JZH003 |
Selective blocker of Nav1.5 |
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ProTx-II |
07PTX002 |
Selective blocker of Nav1.7 |
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ProTx-II Biotin |
12PTB002 |
Selective blocker of Nav1.7 |
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ProTx-I |
12PTX001 |
Blocker of Nav1.8, Nav1.2, Nav1.5, Nav1.7 |
|
Huwentoxin-I |
07HWT001 |
Blocker of TTX-S |
|
Huwentoxin-IV |
08HWT002 |
Blocker of TTX-S |
|
Hainantoxin-III |
13HTX003 |
Blocker of TTX-S |
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Hainantoxin-IV |
12HTX001 |
Blocker of TTX-S |
|
GsAF-I |
12GSF001 |
Blocker of TTX-S |
|
GsAF-II |
12GSF002 |
Blocker of TTX-S |
鉀離子通道(Potassium channel)
|
KCa channels |
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Toxin name |
Catalog # |
Target |
Description |
|
Apamin |
08APA001 |
SK1, SK2, SK3 |
|
|
Charybdotoxin |
11CHA001 |
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6 |
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Iberiotoxin |
12IBX001 |
KCa1.1 |
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Leiurotoxin 1 (Scyllatoxin) |
10LEI001 |
SK1, SK2, SK3 |
|
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Tamapin |
10TAM001 |
SK1, SK2, SK3 |
|
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Kaliotoxin-1 |
08KTX002 |
BK, Kv1.1, Kv1.2, Kv1.3 |
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Kv channels |
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ShK |
08SHK001 |
Kv1.3, Kv1.1, Kv1.4, Kv1.6 |
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TMR-ShK |
SAT001 |
Kv1.3, Kv1.1 |
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Margatoxin |
08MAG001 |
Kv1.3 |
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(Dap22)-ShK |
13SHD001 |
Kv1.3 |
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ADWX-1 |
13ADW001 |
Kv1.3 |
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HsTx1 |
08NEU001 |
Kv1.3, Kv1.2 |
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Agitoxin-2 |
13AGI002 |
Kv1.3, Kv1.1 |
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Maurotoxin |
08MAR001 |
Kv1.2, KCa3.1 |
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Guangxitoxin 1E |
11GUA002 |
Kv2.1, Kv2.2 |
|
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Stromatoxin 1 NEW |
SCT01 |
Kv2.1, Kv2.2 |
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Kaliotoxin-1 |
08KTX002 |
BK, Kv1.1, Kv1.2, Kv1.3 |
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Charybdotoxin |
11CHA001 |
KCa1.1, KCa3.1 - Kv1.2, Kv1.3, Kv1.6 |
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Phrixotoxin-2 |
PHX002 |
Kv4.2, Kv4.3 |
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AmmTx3 NEW |
AMX001 |
A-type potassium channels |
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Inwardly rectifying potassium channels |
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TertiapinQ |
08TER001 |
Kir1.1, Kir3.1/3.4, Kir3.1/3.2-KCa1.1 |
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hERG/Kv11.1 |
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|
BeKm-1 |
13BEK001 |
ERG1 |
|
鈣離子通道(Calcium channel)
|
High voltage-gated Ca2+ channels |
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|
Toxin name |
Catalog# |
Target |
Description |
|
ω-agatoxin IVA |
11AGA001 |
P/Qtype |
|
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ω-Conotoxin MVIIC |
08CON002 |
P/Qtype, N-type |
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ω-Conotoxin MVIIA |
08CON001 |
N-type |
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ω-Conotoxin GVIA |
08CON003 |
N-type |
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ω-Conotoxin SO3 |
08CON013 |
N-type |
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Huwentoxin I |
07HWT001 |
N-type |
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ProTx-II |
07PTX002 |
T-type, L-type |
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Intermediate voltage-gated Ca2+ channels |
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SNX482 |
08SNX002 |
R-type |
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Low voltage-gated Ca2+ channels |
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ProTx-I |
12PTX001 |
T-type |
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ProTx-II |
07PTX002 |
T-type, L-type |
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Maurocalcine |
07PAU001 |
Ryr1 |
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氯離子通道(Chloride channel)
|
Toxin name |
Catalog # |
Target |
Description |
|
Chlorotoxin |
08CHL001 |
Blocker of small conductance Cl- channels |
|
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GaTx1 |
13GTX001 |
Selective blocker of CFTR channel |
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GaTx2 |
10GTX002 |
Selective blocker of ClC-2 channel |
乙酰膽堿受體(Acetylcholine receptor)
|
Toxin name |
Catalog # |
Target |
Description |
|
α-conotoxin PeIA |
13CON017 |
α9α10, α3β2 subunits |
|
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αC-Conotoxin PrXA |
13CON016 |
α1/β1/ε/δ, α1/β1/γ/δ subunits |
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Waglerin-1 |
12WAG001 |
MusclenAChR |
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α-conotoxin MI |
08CON012 |
α1/δsubunits |
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α-conotoxin GI |
08CON005 |
α/δsite |
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α-conotoxin IMI |
08CON011 |
α7 homomeric nAChR |
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α-conotoxin GID |
CON019 |
含N-甲基-D-天冬氨酸NR2B (NMDA, NR2B containing N-methyl-D-aspartate)
Conantokin-G選擇性、特異性抑制含NR2B的NMDAR。Conantokin-G能劑量依賴性抑制Ca2+內(nèi)流，抑制NMDA誘導(dǎo)的興奮性中毒效應(yīng)。研究表明，在小鼠皮層神經(jīng)元，Conantokin-G阻滯NMDA引發(fā)的電流信號(hào)的IC50值為480 nM。
酸敏感離子通道(ASIC channel, Acid-Sensing Ion Channel)
|
Toxin name |
Catalog # |
Target |
Description |
|
APETx2 |
07APE002 |
Selective blocker of ASIC3 |
|
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Psalmotoxin1/PcTx1 |
13PCT001 |
Selective blocker of ASIC1a |
|
|
Ugr9-1 |
13UGR001 |
Blocker of ASIC3 |
瞬時(shí)受體電位(TRP channel, transient receptor potential)
|
Toxin name |
Catalog # |
Target |
Description |
|
GsMTx4 |
08GSM001 |
TRPC, TRPA |
|
|
Vanillotoxin3 |
10VAN003 |
Activator of TRPV1 |
|
|
ProTx-I |
12PTX001 |
Antagonist of TRPA1 |
嘌呤能通道(Purinergic channel)
Purotoxin-1
選擇性抑制P2X3受體。100 nM Purotoxin-1 (PT-1)選擇性抑制P2X3受體通道，在大鼠DRG神經(jīng)元上，使用膜片鉗實(shí)驗(yàn)表明：PT-1對(duì)電壓門(mén)控通道和TRPV1均無(wú)抑制效應(yīng)。10 μM ATP和100 μM α,β Methylene-ATP濃度下Purotoxin-1對(duì)P2X3受體有選擇性作用，在該ATP濃度下Purotoxin-1對(duì)P2X2和雜化二聚體P2X2/3并無(wú)激動(dòng)作用。
Purotoxin-1對(duì)疼痛的潛在**作用。
其它膜受體通道(Others)
Smartox Biotechnology還提供其他類(lèi)型的膜受體抑制劑：
|
Toxin name |
Catalog# |
Target |
|
Morphiceptin |
011CAS001 |
Agonist of μ-opoid receptors |
|
Lys-conopressin G |
11CON14 |
Vasopressin-like peptide |
|
GsMTx4 |
08GSM001 |
Mechano sensitive ion channels |
|
Obtustatin |
10OBT001 |
Blocks the binding of α1β1 integrin to collagen IV |
|
Rho-Conotoxin TIA |
CON022 |
Blocks α1-adrenergic receptor |
